Endocrine Abstracts

Aim: Autoimmune thyroid disease (AITD) is the most common adverse effect in alemtuzumab (ALZ) treated relapsing–remitting (RR) multiple sclerosis (MS) patients. The objective of this prospective study was to analyze the occurrence, timing of onset, clinical course, and laboratory characteristics of AITD post-ALZ and subsequently the clinical outcome of AITD post-ALZ in patients who received ocrelizumab.Patients and methods: We evaluated 36 RRMS pati...

Objective: This study investigated the association between ethnicity, birthplace and emotional and psychosexual wellbeing in women with Polycystic Ovary Syndrome (PCOS) in the community.Design: International cross-sectional study.Methods: Women with a self-reported PCOS diagnosis by a healthcare professional were invited to complete an online Blue Morpho questionnaire between September-October 2020 (UK) and May-June 2021 (India). F...

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder, with an estimated prevalence of 10-15% worldwide. PCOS can have adverse consequences on the emotional wellbeing of the patient. However, evidence exploring the relationship between PCOS and psychosexual wellbeing, specifically sexual function, and dysmorphic appearance concerns, is largely inconclusive.Aim: A systematic review and meta-analysis were undertaken to assess differ...

Introduction: Patients with type 2 diabetes mellitus (T2DM) exert a higher risk for thrombotic events. Platelet reactivity may be used to assess prothrombotic state in such patients. The aim of this study was to investigate whether the administration of novel antidiabetic agents could influence the platelet reactivity in T2DM patients.Patients and methods: We enrolled 99 consecutive patients (males=63.3%), 64.92±8.3 years old, receiving metformin fo...

Introduction: Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine and nervous systems. They most commonly occur in the intestine and are graded histologically according to markers of cellular proliferation. G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) – formerly called carcinoid tumors. G3 neoplasms are called neuroendocrine carcinomas (NECs).Objectives: We present a case of a patient with ...

BackgroundExtranodal non-Hodgkin lymphoma (NHL) is a rare condition that accounts for less than one-third of patients with NHL at diagnosis. The heart or the endocrine organs (adrenals) involvement is extremely rare.ObjectiveWe report an unusual case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma) presenting with heart and bilateral adrenal involvement.Design...

Objectives: This study aimed to assess the results of different perinatal nutritional patterns on skeletal development and insulin regulation of one-year-old Wistar rats.Methods: Three different diet regiments [Control Diet, (CD), food-restricted (FR), or fat-fed (FF)] were randomly provided to sixty-seven primigravid rats from the 12th till the 21st gestational date when they gave birth and throughout the 25-day lactation period. According to...

Objective: Prolactin has been adversely associated with arterial function in postmenopausal women but its vascular effects in reproductive women are unknown. Furthermore, although both circulating prolactin levels and markers of vascular function follow menstrual cycle (MC) phases, their possible inter-correlation has not been explored.Methods: Sixty healthy premenopausal women were evaluated in two distinct phases of their MC (follicular, F and luteal p...

Background: Recent data is indicating that levels of circulating amyloid β 1-40 (αβ1-40), a proatherogenic aging peptide, may be considered as a novel biomarker in cardiovascular disease (CVD). Postmenopausal women represent a population with substantial unrecognized CVD-risk, which would benefit from identification of novel cardiovascular risk markers.Aim: To explore the role of plasma Aβ1-40 and its patterns of change over time in a...

Aims: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) in the general population. However, such a role in patients with familial hypercholesterolemia (FH) is less documented. The purpose of this study was to evaluate the association between Lp(a) concentrations and ASCVD prevalence in adult patients with FH.Methods: This was a cross-sectional study from the Hellenic Familial Hypercholesterolemia Regi...